This book presents best-selected papers presented at the 7th International Conference on Smart Computing and Informatics (SCI 2025), held at the School of Engineering and Technology (SET), Sunway University, Selangor, Malaysia, during 8 - 9 April 2025. It presents advanced and multidisciplinary research towards the design of smart computing and informatics. The theme is on a broader front and focuses on various innovation paradigms in system knowledge, intelligence and sustainability that may be applied to provide realistic solutions to varied problems in society, environment and industries. The scope is also extended towards the deployment of emerging computational and knowledge transfer approaches, optimizing solutions in various disciplines of science, technology and healthcare. The work is published in four volumes.