Yenola Holmes is on the run from the most famous detective in the world - her brother Sherlock Holmes. While wandering through the dark and dangerous streets of London disguised as a doctor's secretary named Evie Michell, she remembers that her real name can be spelled backwards and means "alone". When she finds a hidden cache full of dazzling charcoal drawings, she feels drawn to the girl who drew them...but that girl - Cecily, disappeared under mysterious circumstances. Enola, who believes that appearances cannot last long, takes on the mission of finding her