Sabrina Brooks remains in a coma at Bellevue Hospital, surrounded by government agents.
Meanwhile, another Nightcrawler has surfaced, continuing the struggle against Russian Mob and the Tryzub terror gang. Hoyt Wexford is now in charge of the NYPD's Nightcrawler Squad, ordered to apprehend the rogue crime fighter.
Time is of the essence as a new terror cell under the mysterious Apollyon arises. Their demand: a $100 million ransom, or they unleash a mutated Ebola strain upon the populace of NYC.
Is the new Nightcrawler their only hope, or can Hoyt find the masked avenger and learn his secrets before it is too late?
