This book centres on women living with HIV in South Africa who have navigated affective relationships, activist networks, government institutions and global coalitions to transform health policies that govern access to HIV medicines. Drawing on 20 years of ethnographic and policy research in South Africa, Brazil and India, it highlights the value of understanding the embodied and political dimensions of health policy and reveals the networked threads that weave women's precarity into the governance of technologies and the technologies of governance. It illuminates the entwined histories of health policy evolution, systemic inequality and everyday life and calls for a recognition of the embodied ramifications of democratic politics and global health governance. By integrating medical anthropology with science studies and political theory, this book traces the history of the struggle to access HIV medicines in the Global South and brings it into the present by articulating the lessons learned by activists and policy makers engaged in shaping vital health policies.