This quantitative study identifie factors affecting tourist perception in the context of rural tourism in Ca Mau province - the southernmost province of Vietnam, belonging to the Mekong Delta. In which, local culture, infrastructure and marketing communication has positive relation with tourist perception, while services & entertainment has negative relation. The research produced 400 structured questionnaires to collect data on these factors in Ca Mau, and found that there is a significant influence on tourist perception in rural tourism sector, which 58% changing in tourist perception is explained by the independent variables.